Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
نویسندگان
چکیده
منابع مشابه
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
In hypercholesterolemia, impaired nitric oxide activity has been associated with increased nitric oxide degradation by oxygen radicals. Deficiency of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase, causes both impaired nitric oxide activity and increased oxygen radical formation. In this study we tested whether tetrahydrobiopterin deficiency contributes to the decreased nit...
متن کاملTetrahydrobiopterin restores endothelial function in long-term smokers.
OBJECTIVES We sought to test whether tetrahydrobiopterin (BH4) supplementation improves nitric oxide (NO) bioactivity in smokers. BACKGROUND In smokers, endothelium-derived NO bioactivity is impaired. BH4 is an essential cofactor of NO synthase, and its deficiency decreases NO bioactivity. METHODS Sapropterin hydrochloride, an active analogue of BH4 (2 mg/kg body weight), was administered o...
متن کاملTetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia.
OBJECTIVE To examine the effect of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase, on coronary artery endothelial function in hypercholesterolaemic patients. DESIGN Quantitative coronary angiography and Doppler flowmetry were used to examine the effects of intracoronary infusion of BH4 on vascular response to acetylcholine (ACh). SETTING Tertiary cardiology centr...
متن کاملBASIC RESEARCH Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
Objective: To examine the effect of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase, on coronary artery endothelial function in hypercholesterolaemic patients. Design: Quantitative coronary angiography and Doppler flowmetry were used to examine the effects of intracoronary infusion of BH4 on vascular response to acetylcholine (ACh). Setting: Tertiary cardiology centre...
متن کامل5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
BACKGROUND Impaired nitric oxide (NO) activity is an early event in the pathogenesis of cardiovascular disease, resulting from either reduced NO formation or increased NO degradation. Administration of tetrahydrobiopterin (BH4), an essential cofactor for NO production, could restore NO activity in familial hypercholesterolemia (FH). Because folates have been suggested to stimulate endogenous BH...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119131